Melorheostosis is bone condition caused by cellular changes in the LEMD3 gene. The condition is relatively rare and cannot be passed down to succeeding generations, although the symptoms worsen over time. Its primary characteristic is a thickening of the bone of the cortex, which can be detected almost immediately after birth. The condition starts out benign, but begins to cause a number of painful and distressing symptoms as it progresses. Patients with melorheostosis may experience reduced mobility and range of movement due to abnormal bone development. They may also experience sensitivity to cold and hyperpigmentation, and they often have to deal with considerable pain. For patients suffering from melorheostosis, marijuana may help ease the pain and discomfort associated with the condition.